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Circumcision 'reduces HIV risk'

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GCG
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« on: October 29, 2010, 11:25:36 AM »

http://www.news24.com/SouthAfrica/AidsFocus/Circumcision-reduces-HIV-risk-20090415
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"Research on the effectiveness of male circumcision for preventing HIV in heterosexual men is conclusive," said lead researcher Nandi Siegfried, co-director of the centre, which is located at the SA Medical Research Council.

Quote
Siegfried said circumcision might help to protect against HIV by removing cells in the foreskin to which the virus was specifically attracted.

These Langerhans cells had receptors that enabled the virus to enter them.


i don't know about this.  it sounds a little dodge in my opinion...
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Faerie
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« Reply #1 on: October 29, 2010, 11:47:27 AM »

Apparently a lot of research was done on this, I know in KZN a couple months ago they had a drive and some 3000 men were circumcised. I have no clue as to the validity of the claim though, I do suppose that it improves cleanliness in the area?  Undecided
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Sayman
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« Reply #2 on: November 02, 2010, 11:55:07 AM »

Hi Smiley

Time for one of the lurkers to make himself known hehehe.  I’m currently doing my degree in biochemistry at WITS. When I did a course called molecular basis of disease, we came across this topic. A lot of research has gone into this as far as I know. I’m too busy studying for my final biochem ...(which is tomorrow  Shocked ) to actually look up the references, but I’ll try to post them soon. There are a lot of cells located in the foreskin that HIV target specifically. However there have been positive and negative studies, but more positive ones.

Now I really need to stop procrastinating doh.


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Mefiante
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« Reply #3 on: November 02, 2010, 12:22:46 PM »

Welcome, and good luck with your exam! Smiley

'Luthon64
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GCG
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« Reply #4 on: November 02, 2010, 12:28:37 PM »

it feels to me, that this is just an excuse for men to not use protection.
this article states, that it 'reduces' the risk of infection for the first two years.
then what?
and what about he woman then?
if the guy is allready infected, how the hell would cutting the foreskin help her?

im sure there is validity in this claim, but in this country, where the accountability for std spreading is nil, such half-baked solutions isnt worth a crap.
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BoogieMonster
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« Reply #5 on: November 02, 2010, 13:37:58 PM »

Yeah but see, that's making the problem more complex than the root question alludes to.

Does circumcision help to prevent transmission? From where I stand, yes.

That is perhaps just one dimension of a much larger matrix of inputs we're dealing with here, but I think the IDEA has merit.

The other problems, to do with people ceasing the use of protection, etc. Is a societal problem that needs to be addressed separately. To be fair, if you're sleeping around in this day and age without protection you are either highly ignorant or very irresponsible, and circumcision won't change that, but it may, to a small degree, protect you.

My point is, you can't just do the cut and think it's a 100% solution. Other protective measures need to be in place too, and people need to be EDUCATED! In this kind of circumstance, if doing the cut can save a certain percentage of people who are acting in these vicarious ways, it has merit FOR THE POPULATION, even if it doesn't seem to make sense on an individual level.

EDIT: To repeat myself once more and for clarity: When you are an individual, and lets say, you have a 5% smaller chance of transmission from getting the cut, it looks pretty shit. But if you're dept. of health, 5% is possibly hundreds of thousands of lives saved.
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GCG
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« Reply #6 on: November 02, 2010, 14:46:21 PM »

agreed about the education end of things.  but since our government is still punting beetroot and garlic as cures for aids, and so busy enriching themselves, off budgets that could have spread education far and wide....  our goverment is not interrested in saving lives. 
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BoogieMonster
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« Reply #7 on: November 05, 2010, 16:52:29 PM »

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government is still punting beetroot and garlic as cures for aids

I thought that dogma had been abandoned? no?

(I'm am hopelessly uninformed on the subject)
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Brian
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« Reply #8 on: November 10, 2010, 17:10:42 PM »

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government is still punting beetroot and garlic as cures for aids

I thought that dogma had been abandoned? no?

(I'm am hopelessly uninformed on the subject)
so were they BM!
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Cep
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« Reply #9 on: November 11, 2010, 13:34:36 PM »

It is sure to prevent HIV for at least as long as the healing process takes.
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GCG
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« Reply #10 on: November 11, 2010, 13:37:50 PM »

how do you recon that?
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Cep
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« Reply #11 on: November 11, 2010, 13:42:26 PM »

how do you recon that?...... No sexual activity will take place.
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« Reply #12 on: November 11, 2010, 14:48:36 PM »

how do you recon that?
oops as I said.
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GCG
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« Reply #13 on: November 11, 2010, 15:36:01 PM »

ha ha.  for sure that!
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« Reply #14 on: November 12, 2010, 09:52:52 AM »

Folks: it's a simple issue.  The inside of a foreskin is a nice, damp, sensitive area of epithelial tissue, fairly easily damaged, which lets HIV in, and which has a LOT of the sorts of cells which can take up HIV and present it to CD4+ T-cells to infect them - namely, dendritic cells.

Circumcision removes the sensitive bit, and allows the glans of the penis - also more susceptible in the uncircumcised - to become more cornified, or to develop a thicker layer of dead cells (aka "skin"), which acts as a passive barrier to HIV entry.

There now: not so hard, was it?  Oops, a pun... Cool
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